Force and the spindle: Mechanical cues in mitotic spindle orientation
نویسندگان
چکیده
منابع مشابه
Force and Length in the Mitotic Spindle
The mitotic spindle assembles to a steady-state length at metaphase through the integrated action of molecular mechanisms that generate and respond to mechanical forces. While molecular mechanisms that produce force have been described, our understanding of how they integrate with each other, and with the assembly/disassembly mechanisms that regulate length, is poor. We review current understan...
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Metaphase and anaphase spindles in cultured newt and PtK1 cells were irradiated with a UV microbeam (285 nM), creating areas of reduced birefringence (ARBs) in 3 s that selectively either severed a few fibers or cut across the half spindle. In either case, the birefringence at the polewards edge of the ARB rapidly faded polewards, while it remained fairly constant at the other, kinetochore edge...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2014
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2014.07.008